My 60-something mother is extremely antisocial and odd. Help.?

She sounds as if she may be clinically depressed, or as you say in the early stages of some kind of dementia. However she is the so called "sandwich" generation, who have responsibilities for younger and also older family members. Do you think she may be feeling overwhelmed by all these imagined or real responsibilities ? That could be at the root of her withdrawal from the life of those around her,or it could be sheer laziness ? Is the housework getting done ? Is she keeping the place spotless or are things domestically going downhill ? You are right, the more she isolates herself the worse she will become. Can you get her to see a doctor and at least get routine bloods done to rule out anything physical.